Sex-biased immunogenicity of a mucosal subunit vaccine against SARS-CoV-2 in mice.

ABSTRACT:

Introduction

Current vaccines against COVID-19 administered via parenteral route have limited ability to induce mucosal immunity. There is a need for an effective mucosal vaccine to combat SARS-CoV-2 virus replication in the respiratory mucosa. Moreover, sex differences are known to affect systemic antibody responses against vaccines. However, their role in mucosal cellular responses against a vaccine remains unclear and is underappreciated.

Methods

We evaluated the mucosal immunogenicity of a booster vaccine regimen that is recombinant protein-based and administered intranasally in mice to explore sex differences in mucosal humoral and cellular responses.

Results

Our results showed that vaccinated mice elicited strong systemic antibody (Ab), nasal, and bronchiole alv

SUBMITTER: Li J 

PROVIDER: S-EPMC11148259 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature