Canine peripheral non-conventional TCRαβ⁺ CD4^-CD8α^- double-negative T cells show T helper 2-like and regulatory properties.

ABSTRACT: The dog is an important companion animal and also serves as model species for human diseases. Given the central role of T cells in immune responses, a basic understanding of canine conventional T cell receptor (TCR)αβ⁺ T cells, comprising CD4⁺ single-positive (sp) T helper (Th) and CD8α⁺ sp cytotoxic T cell subsets, is available. However, characterization of canine non-conventional TCRαβ⁺ CD4⁺CD8α⁺ double-positive (dp) and TCRαβ⁺ CD4^-CD8α^- double-negative (dn) T cells is limited. In this study, we performed a comprehensive analysis of canine dp and dn T cells in comparison with their conventional counterparts. TCRαβ⁺ T cells from peripheral blood of healthy dogs were sorted accordi

SUBMITTER: Protschka M 

PROVIDER: S-EPMC11148280 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature