Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers.

ABSTRACT:

Background

Ankylosing spondylitis (AS) is a complex condition with a significant genetic component. This study explored circulating proteins as potential genetic drug targets or biomarkers to prevent AS, addressing the need for innovative and safe treatments.

Methods

We analyzed extensive data from protein quantitative trait loci (pQTLs) with up to 1,949 instrumental variables (IVs) and selected the top single-nucleotide polymorphism (SNP) associated with AS risk. Utilizing a two-sample Mendelian randomization (MR) approach, we assessed the causal relationships between identified proteins and AS risk. Colocalization analysis, functional enrichment, and construction of protein-protein interaction networks further supported these findings. We utilized phenome-wide MR (phenMR)

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11148386 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature