Circulating miRNA Signature Predicts Cancer Incidence in Lynch Syndrome-A Pilot Study.

ABSTRACT: Lynch syndrome (LS) is the most common autosomal dominant cancer syndrome and is characterized by high genetic cancer risk modified by lifestyle factors. This study explored whether a circulating miRNA (c-miR) signature predicts LS cancer incidence within a 4-year prospective surveillance period. To gain insight how lifestyle behavior could affect LS cancer risk, we investigated whether the cancer-predicting c-miR signature correlates with known risk-reducing factors such as physical activity, body mass index (BMI), dietary fiber, or NSAID usage. The study included 110 c-miR samples from LS carriers, 18 of whom were diagnosed with cancer during a 4-year prospective surveillance period. Lasso regression was utilized to find c-miRs associated with cancer risk. Individual risk sum derived fro

SUBMITTER: Sievanen T 

PROVIDER: S-EPMC11148538 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature