Nature-Derived Gelatin-Based Antifungal Nanotherapeutics for combatting <i>Candida albicans</i> Biofilms.

ABSTRACT: Infections caused by fungi are emerging global health challenges that are exacerbated by the formation of fungal biofilms. Further challenges arise from environmental contamination with antifungal agents, which promotes environmental acquisition of antifungal resistance. We report the generation of an efficient, sustainable, all-natural antifungal nanotherapeutic based on the integration of an antimicrobial natural essential oil into a gelatin-based nanoemulsion platform. Carvacrol-loaded gelatin nanoemulsions penetrated Candida albicans biofilms, resulting in death of C. albicans cells in biofilms, and displayed selective biofilm elimination without harmful effects on fibroblast cells in a fungal biofilm-mammalian fibroblast co-culture model. Furthermore, the nanoemulsions d

SUBMITTER: Nabawy A 

PROVIDER: S-EPMC11149111 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature