IFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) is a common disease in the urinary system, with a high incidence and poor prognosis in advanced stages. Although γ-interferon-inducible protein 16 (IFI16) has been reported to play a role in various tumors, its involvement in ccRCC remains poorly documented, and the molecular mechanisms are not yet clear.

Methods

We conducted bioinformatics analysis to study the expression of IFI16 in ccRCC using public databases. Additionally, we analyzed and validated clinical specimens that we collected. Subsequently, we explored the impact of IFI16 on ccRCC cell proliferation, migration, and invasion through in vitro and in vivo experiments. Furthermore, we predicted downstream molecules and pathways using transcriptome analysis and conf

SUBMITTER: Lu K 

PROVIDER: S-EPMC11149187 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature