Determinants of overall survival in patients with metastatic uveal melanoma.

ABSTRACT:

Background

Despite improvements in the treatment of primary uveal melanoma (UM), patients with metastatic disease continue to exhibit poor survival.

Methods

A retrospective review of metastatic UM patients at Yale (initial cohort) and Memorial Sloan Kettering (validation cohort) was conducted. Cox proportional hazards regression was used to determine baseline factors that are associated with overall survival, including sex, Eastern Cooperative Oncology Group (ECOG) Performance Status Scale, laboratory measurements, metastasis location, and use of anti-CTLA-4 and anti-PD-1 therapies. Differences in overall survival were analyzed using Kaplan-Meier analysis.

Results

A total of 89 patients with metastatic UM were identified; 71 and 18, in the initial and validation cohor

SUBMITTER: Demkowicz P 

PROVIDER: S-EPMC11149607 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature