Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift.

ABSTRACT: Avian influenza viruses evolve antigenically to evade host immunity. Two influenza A virus surface glycoproteins, the haemagglutinin and neuraminidase, are the major targets of host immunity and undergo antigenic drift in response to host pre-existing humoral and cellular immune responses. Specific sites have been identified as important epitopes in prominent subtypes such as H5 and H7, which are of animal and public health significance due to their panzootic and pandemic potential. The haemagglutinin is the immunodominant immunogen, it has been extensively studied, and the antigenic reactivity is closely monitored to ensure candidate vaccine viruses are protective. More recently, the neuraminidase has received increasing attention for its role as a protective immunogen. The neuraminidase

SUBMITTER: Luczo JM 

PROVIDER: S-EPMC11149724 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature