YQTL Pipeline: A structured computational workflow for large scale quantitative trait loci discovery and downstream visualization.

ABSTRACT: Quantitative trait loci (QTL) denote regions of DNA whose variation is associated with variations in quantitative traits. QTL discovery is a powerful approach to understand how changes in molecular and clinical phenotypes may be related to DNA sequence changes. However, QTL discovery analysis encompasses multiple analytical steps and the processing of multiple input files, which can be laborious, error prone, and hard to reproduce if performed manually. To facilitate and automate large-scale QTL analysis, we developed the yQTL Pipeline, where the 'y' indicates the dependent quantitative variable being modeled. Prior to the association test, the pipeline supports the calculation or the direct input of pre-defined genome-wide principal components and genetic relationship matrix when applicab

SUBMITTER: Li M 

PROVIDER: S-EPMC11149833 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature