Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits.

ABSTRACT:

Background

Polymorphisms in the gene encoding for metabotropic glutamate receptor 3 (mGlu₃) are associated with an increased likelihood of schizophrenia diagnosis and can predict improvements in negative symptoms following treatment with antipsychotics. However, the mechanisms by which mGlu₃ can regulate brain circuits involved in schizophrenia pathophysiology are not clear.

Methods

We employed selective pharmacological tools and a variety of approaches including whole-cell patch-clamp electrophysiology, slice optogenetics, and fiber photometry to investigate the effects of mGlu₃ activation on phencyclidine (PCP)-induced impairments in thalamo-accumbal transmission and sociability deficits. A chemogenetic approach was used to evaluate the rol

SUBMITTER: Dogra S 

PROVIDER: S-EPMC11150332 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature