SIRPG expression positively associates with an inflamed tumor microenvironment and response to PD-1 blockade.

ABSTRACT:

Background

This study aimed to investigate the relationship between signal regulatory protein gamma (SIRPG) and tumor immune microenvironment phenotypes or T cell mediated-adaptive antitumor immunity, and its predictive value for response to PD-1 blockade in cancers.

Methods

Pan-cancer analysis of SIRPG expression and immune deconvolution was performed using transcriptomic data across 33 tumor types. Transcriptomic and clinical data from 157 patients with non-small-cell lung cancer (NSCLC) and melanoma received PD-1 blockade were analyzed. Expression characteristics of SIRPG were investigated using single-cell RNA sequencing (scRNA-seq) data of 103,599 cells. The effect of SIRPG expression was evaluated via SIRPG knockdown or overexpression in Jurkat T cells.

Results

SUBMITTER: Luo L 

PROVIDER: S-EPMC11150346 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature