Diastolic and systolic blood pressure and gout: a Mendelian randomization study.

ABSTRACT:

Background

Although there is solid epidemiological evidence supporting the connection between hypertension and gout, little has been said about the relationship between diastolic and systolic blood pressure and gout, the causal relationship and direction associated are uncertain, so we aim to research the causal relationship between diastolic and systolic blood pressure and gout.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal effect between 2 blood pressure phenotypes (including diastolic blood pressure and systolic blood pressure) and 5 gout phenotypes (including gout, drug-induced gout, idiopathic gout, unspecified gout, and strictly defined gout) using genome-wide association study statistics. The inverse variance weighting me

SUBMITTER: Li Y 

PROVIDER: S-EPMC11150642 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature