Non-High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events.

ABSTRACT:

Importance

Elevated non-high-density lipoprotein cholesterol (non-HDL-C; a recommended measure of lipid-related cardiovascular risk) is common in children and increases risk of adult cardiovascular disease (CVD). Whether resolution of elevated childhood non-HDL-C levels by adulthood is associated with reduced risk of clinical CVD events is unknown.

Objective

To examine the associations of non-HDL-C status between childhood and adulthood with incident CVD events.

Design, setting, and participants

Individual participant data from 6 prospective cohorts of children (mean age at baseline, 10.7 years) in the US and Finland. Recruitment took place between 1970 and 1996, with a final follow-up in 2019.

Exposures

Child (age 3-19 years) and adult (age 20-40 years) non-HD

SUBMITTER: Wu F 

PROVIDER: S-EPMC11151142 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature