Protein arginine methyltransferase 1 regulates mouse enteroendocrine cell development and homeostasis.

ABSTRACT:

Background

The adult intestinal epithelium is a complex, self-renewing tissue composed of specialized cell types with diverse functions. Intestinal stem cells (ISCs) located at the bottom of crypts, where they divide to either self-renew, or move to the transit amplifying zone to divide and differentiate into absorptive and secretory cells as they move along the crypt-villus axis. Enteroendocrine cells (EECs), one type of secretory cells, are the most abundant hormone-producing cells in mammals and involved in the control of energy homeostasis. However, regulation of EEC development and homeostasis is still unclear or controversial. We have previously shown that protein arginine methyltransferase (PRMT) 1, a histone methyltransferase and transcription co-activator, is important for

SUBMITTER: Peng Z 

PROVIDER: S-EPMC11151601 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature