Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD).

Methods

The study comprised data from three genome-wide association studies involving individuals of European ancestry. The study groups included participants with celiac disease (n = 24,269), CKD (n = 117,165), and estimated glomerular filtration rate levels based on serum creatinine (eGFRcrea, n = 133,413). We employed four widely recognized causal inference algorithms: MR-Egger, inverse variance weighted (IVW), weighted median, and weighted mode. To address potential issues related to pleiotropy and overall effects, MR-Egger regression and the MR-PRESSO global test were performed. Hete

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11151793 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature