S-EPMC11151861 - De novo design of peptides that bind specific conformers of α-synuclein† † Electronic supplementary information (ESI) available: Procedures for the design pipeline; preparation of αSyn fibrils (WT, E46K, rod, and fibril), and Aβ40 and 0N3R tau fibrils; peptide synthesis; ligand depletion sedimentation assay; ThT fluorescence assays; confocal imaging; characterization data (ESI-MS and HPLC traces) for peptide 4, peptide 4*, and scramble*. See DOI: https://doi.org/10.1039/d3sc06245g