Impact of Tumor Shrinkage Pattern with Biweekly Triplet Gemcitabine+Cisplatin+S-1 Regimen for Biliary Tract Cancers: Implications for Neoadjuvant Therapy from the Data of KHBO1401 (KHBO1401-1A Study).

ABSTRACT:

Introduction

The multicenter randomized phase III KHBO1401 study (gemcitabine+cisplatin+S-1 [GCS] vs. GC in biliary tract cancers [BTC]) demonstrated that GCS not only prolonged patient survival but also achieved a high response rate and that it should be good for neoadjuvant therapy. Therefore, to explore the possibilities of neoadjuvant therapy, we investigated the tumor shrinkage pattern.

Methods

Among the total of 246 patients enrolled in the KHBO1401, the tumor shrinkage pattern and survival were investigated in patients with measurable BTC (n = 183, 74%; GCS, n = 91; GC, n = 92).

Results

The tumor shrinkage pattern could be divided into 4 categories based on the response at 100 days after enrollment: categories A (<-30% in size), B (-30-0%), C (0% to +20%), a

SUBMITTER: Kobayashi S 

PROVIDER: S-EPMC11152028 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature