Investigation of a chondroitin sulfate-based bioactive coating for neural interface applications.

ABSTRACT: Invasive neural implants allow for high-resolution bidirectional communication with the nervous tissue and have demonstrated the ability to record neural activity, stimulate neurons, and sense neurochemical species with high spatial selectivity and resolution. However, upon implantation, they are exposed to a foreign body response which can disrupt the seamless integration of the device with the native tissue and lead to deterioration in device functionality for chronic implantation. Modifying the device surface by incorporating bioactive coatings has been a promising approach to camouflage the device and improve integration while maintaining device performance. In this work, we explored the novel application of a chondroitin sulfate (CS) based hydrophilic coating, with anti-fouling and ne

SUBMITTER: Dhawan V 

PROVIDER: S-EPMC11152038 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature