Exploring the Role and Prognostic Value of TMEM208 in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Objective

Head and neck squamous cell carcinoma (HNSCC) is one of the world's eight most common malignancies and a severe hazard to human health. Transmembrane protein 208 (TMEM208) has been reported to be associated with autophagy,which is strongly tied to the onset and development of numerous illnesses, including cancer. For this reason, we investigated the expression and prognostic significance of TMEM208 in HNSCC.

Methods

To explore the role and molecular mechanism of this gene in HNSCC, we performed a comprehensive analysis of the TMEM208 gene, including gene expression analysis, prognostic analysis, and immune infiltration analysis using the UALCAN, HPA, CVCDAP, DAVID, TIMER, CIBERSORTx, TISIDB, and cBioPortal online databases. It was further validated by in vitro cell

SUBMITTER: Yang J 

PROVIDER: S-EPMC11152404 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature