Genetic regulation of injury-induced heterotopic ossification in adult zebrafish.

ABSTRACT: Heterotopic ossification is the inappropriate formation of bone in soft tissues of the body. It can manifest spontaneously in rare genetic conditions or as a response to injury, known as acquired heterotopic ossification. There are several experimental models for studying acquired heterotopic ossification from different sources of damage. However, their tenuous mechanistic relevance to the human condition, invasive and laborious nature and/or lack of amenability to chemical and genetic screens, limit their utility. To address these limitations, we developed a simple zebrafish injury model that manifests heterotopic ossification with high penetrance in response to clinically emulating injuries, as observed in human myositis ossificans traumatica. Using this model, we defined the transcripti

SUBMITTER: Kaliya-Perumal AK 

PROVIDER: S-EPMC11152560 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature