Structures of human γδ T cell receptor-CD3 complex.

ABSTRACT: Gamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune responses and immunopathology^1-3. The γδ T cell receptor (TCR), which is generated by γδ T cells, recognizes a diverse range of antigens independently of the major histocompatibility complex². The γδ TCR associates with CD3 subunits, initiating T cell activation and holding great potential in immunotherapy⁴. Here we report the structures of two prototypical human Vγ9Vδ2 and Vγ5Vδ1 TCR-CD3 complexes^5,6, revealing two distinct assembly mechanisms that depend on Vγ usage. The Vγ9Vδ2 TCR-CD3 complex is monomeric, with considerable conformational flexibility in the TCRγ-TCRδ extracellular domain and connecting peptides. The length of the connecting peptides regulates the

SUBMITTER: Xin W 

PROVIDER: S-EPMC11153141 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature