Natural proteome diversity links aneuploidy tolerance to protein turnover.

ABSTRACT: Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory findings to be assessed. One notable discovery made in natural isolates of Saccharomyces cerevisiae is that aneuploidy-an imbalance in chromosome copy numbers-is frequent^1,2 (around 20%), which seems to contradict the substantial fitness costs and transient nature of aneuploidy when it is engineered in the laboratory^3-5. Here we generate a proteomic resource and merge it with genomic¹ and transcriptomic⁶ data for 796 euploid and aneuploid natural isolates. We find that natural and lab-generated aneuploids differ specifically at the proteome. In lab-generated aneuploids, some proteins-especially s

SUBMITTER: Muenzner J 

PROVIDER: S-EPMC11153158 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature