New insights into the domain of unknown function (DUF) of EccC₅, the pivotal ATPase providing the secretion driving force to the ESX-5 secretion system.

ABSTRACT: Type VII secretion (T7S) systems, also referred to as ESAT-6 secretion (ESX) systems, are molecular machines that have gained great attention due to their implications in cell homeostasis and in host-pathogen interactions in mycobacteria. The latter include important human pathogens such as Mycobacterium tuberculosis (Mtb), the etiological cause of human tuberculosis, which constitutes a pandemic accounting for more than one million deaths every year. The ESX-5 system is exclusively found in slow-growing pathogenic mycobacteria, where it mediates the secretion of a large family of virulence factors: the PE and PPE proteins. The secretion driving force is provided by EccC₅, a multidomain ATPase that operates using four globular cytosolic domains: an N-terminal domain of unknown f

SUBMITTER: Ceballos-Zuniga F 

PROVIDER: S-EPMC11154593 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature