M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction.

ABSTRACT:

Background

Myocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction angiogenesis remains unclear.

Methods

In this study, we explored the role and mechanism of action of M2 macrophage-derived exosomes (M2-exos) in angiogenesis after MI. M2-exos were harvested and injected intramyocardially at the onset of MI. Two distinct endothelial cells (ECs) were cultured with M2-exos to explore the direct effects on angiogenesis.

Results

We showed that M2-exos improved cardiac function, reduced infarct size, and enhanced angiogenesis after MI. Moreover, M2-exos promoted angiogenesis in vitro; the molecules loaded in the vesicles were responsible for its proangiogenic effects. We further validated that high

SUBMITTER: Guo H 

PROVIDER: S-EPMC11155164 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature