Letrozole delays acquisition of water maze task in female BALB/c mice: Possible involvement of anxiety.

ABSTRACT: Letrozole, an aromatase inhibitor preventing estrogen synthesis from testosterone, is used as an adjuvant therapy in estrogen receptor-positive breast cancer patients. However, like other aromatase inhibitors, it induces many side effects, including impaired cognition. Despite its negative effect in humans, results from animal models are inconsistent and suggest that letrozole can either impair or improve cognition. Here, we studied the effects of chronic letrozole treatment on cognitive behavior of adult female BALB/c mice, a relevant animal model for breast cancer studies, to develop an appropriate animal model aimed at testing therapies to mitigate side effects of letrozole. In Morris water maze, letrozole 0.1 mg/kg impaired reference learning and memory. Interestingly, most of the letr

SUBMITTER: Mamczarz J 

PROVIDER: S-EPMC11155665 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature