Congested C(sp3)-rich architectures enabled by iron-catalysed conjunctive alkylation.

ABSTRACT: Catalytic cross-coupling by transition metals has revolutionized the formation of C-C bonds in organic synthesis. However, the challenge of forming multiple alkyl-alkyl bonds in crowded environments remains largely unresolved. Here, we report the regioselective functionalization of olefins with sp³-hybridized organohalides and organozinc reagents using a simple (terpyridine)iron catalyst. Aliphatic groups of various sizes are successfully installed on either olefinic carbon, furnishing a diverse array of products with congested cores featuring C- or heteroatom-substituted stereocenters. The method enables access to valuable but synthetically challenging C(sp³)-rich molecules, including alicyclic compounds bearing multiple contiguous stereocenters through annulation ca

SUBMITTER: Tan TD 

PROVIDER: S-EPMC11155680 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature