DIAPH2 gene polymorphisms and laryngeal cancer risk in men.

ABSTRACT:

Background

The DIAPH2 gene is one of the genes commonly associated with laryngeal squamous cell carcinoma (LSCC). In our study, we considered the four polymorphisms of this gene, i.e. rs5920828, rs4322175, rs12851931 and rs5921830 as potential genetic risk factors for LSCC.

Methods

We determined the genotyping of the genetic variants of DIAPH2 in 230 male patients with histologically confirmed LSCC compared to the European population. Demographic and environmental exposure data of each subject were examined. To conduct the genetic tests, extraction of total DNA was performed. We genotyped all four variants in each patient and determined their frequencies.

Results

In the case of the rs12851931 polymorphism in the DIAPH2 gene, a significant difference was observed in th

SUBMITTER: Cichocka E 

PROVIDER: S-EPMC11156712 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature