Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study.

ABSTRACT:

Background

The clinical value of the trajectory of temporal changes in acute kidney injury (AKI) biomarkers has not been well established among intensive care unit (ICU) patients.

Methods

This is a single-center, prospective observational study, performed at a mixed ICU in a teaching medical institute in Tokyo, Japan. Adult ICU patients with an arterial line and urethral catheter were enrolled from September 2014 to March 2015. Patients who stayed in the ICU for less than 48 h and patients with known end-stage renal disease were excluded from the study. Blood and urine samples were collected for measurement of AKI biomarkers at 0, 12, 24, and 48 h after ICU admission. The primary outcome was major adverse kidney events (MAKE) at discharge, defined as a composite of death, di

SUBMITTER: Horie R 

PROVIDER: S-EPMC11156822 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature