Deficiency of SDHC promotes metastasis by reprogramming fatty acid metabolism in colorectal cancer.

ABSTRACT:

Background

Several studies have demonstrated a strong correlation between impaired Succinate dehydrogenase (SDH) function and the advancement of tumors. As a subunit of SDH, succinate dehydrogenase complex subunit C (SDHC) has been revealed to play tumor suppressive roles in several cancers, while its specific role in colorectal cancer (CRC) still needs further investigation.

Methods

Online database were utilized to investigate the expression of SDHC in colorectal cancer and to assess its correlation with patient prognosis. Cell metastasis was assessed using transwell and wound healing assays, while tumor metastasis was studied in a nude mice model in vivo. Drug screening and RNA sequencing were carried out to reveal the tumor suppressor mechanism of SDHC. Triglycerides, neu

SUBMITTER: Ding Z 

PROVIDER: S-EPMC11157952 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature