Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.

ABSTRACT: We characterized the genetic architecture of the attention-deficit hyperactivity disorder-substance use disorder (ADHD-SUD) relationship by investigating genetic correlation, causality, pleiotropy, and common polygenic risk. Summary statistics from genome-wide association studies (GWAS) were used to investigate ADHD (N_eff = 51,568), cannabis use disorder (CanUD, N_eff = 161,053), opioid use disorder (OUD, N_eff = 57,120), problematic alcohol use (PAU, N_eff = 502,272), and problematic tobacco use (PTU, N_eff = 97,836). ADHD, CanUD, and OUD GWAS meta-analyses included cohorts with case definitions based on different diagnostic criteria. PAU GWAS combined information related to alcohol use disorder, alcohol dependence, and the items related

SUBMITTER: Koller D 

PROVIDER: S-EPMC11157987 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature