Cancer risks among first-degree relatives of women with a genetic predisposition to breast cancer.

ABSTRACT:

Background

Associations between germline alterations in women and cancer risks among their relatives are largely unknown.

Methods

We identified women from 2 Swedish cohorts Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) and prevalent KARMA (pKARMA), including 28 362 women with genotyping data and 13 226 with sequencing data. Using Swedish Multi-Generation Register, we linked these women to 133 389 first-degree relatives. Associations between protein-truncating variants in 8 risk genes and breast cancer polygenic risk score in index women and cancer risks among their relatives were modeled via Cox regression.

Results

Female relatives of index women who were protein-truncating variant carriers in any of the 8 risk genes had an increased brea

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC11160497 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature