Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants.

ABSTRACT:

Introduction

Electrophysiology and plasma biomarkers are early and non-invasive candidates for Alzheimer's disease detection. The purpose of this paper is to evaluate changes in dynamic functional connectivity measured with magnetoencephalography, associated with the plasma pathology marker p-tau231 in unimpaired adults.

Methods

73 individuals were included. Static and dynamic functional connectivity were calculated using leakage corrected amplitude envelope correlation. Each source's strength entropy across trials was calculated. A data-driven statistical analysis was performed to find the association between functional connectivity and plasma p-tau231 levels. Regression models were used to assess the influence of other variables over the clusters' connectivity.

Results<

SUBMITTER: Carrasco-Gomez M 

PROVIDER: S-EPMC11160744 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature