Structural dynamics of the intrinsically disordered linker region of cardiac troponin T.

ABSTRACT: The cardiac troponin complex, composed of troponins I, T, and C, plays a central role in regulating the calcium-dependent interactions between myosin and the thin filament. Mutations in troponin can cause cardiomyopathies; however, it is still a major challenge to connect how changes in sequence affect troponin's function. Recent high-resolution structures of the thin filament revealed critical insights into the structure-function relationship of troponin, but there remain large, unresolved segments of troponin, including the troponin-T linker region that is a hotspot for cardiomyopathy mutations. This linker region is predicted to be intrinsically disordered, with behaviors that are not well described by traditional structural approaches; however, this proposal has not been experimentally

SUBMITTER: Cubuk J 

PROVIDER: S-EPMC11160775 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature