Examining the causal relationship between sex hormone-binding globulin (SHBG) and infertility: A Mendelian randomization study.

ABSTRACT:

Background

The causal relationship between sex hormone-binding globulin (SHBG) and infertility has remained unclear. Thus, we used Mendelian randomization (MR) to investigate this relationship.

Methods

Risk factors for SHBG were extracted from European individuals within the UK Biobank using single-nucleotide polymorphism (SNP) data. Summary-level data for infertility outcomes were obtained from the FinnGen dataset. The causal relationship between SHBG and infertility was examined using inverse variance weighted, weighted model, weighted median, and MR-Egger regression analyses. Additionally, Cochran's Q test and Egger intercept tests were used to confirm the heterogeneity and pleiotropy of identified instrumental variables (IVs).

Results

Our findings revealed a signi

SUBMITTER: Ma H 

PROVIDER: S-EPMC11161117 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature