A genome-wide association study reveals a polygenic architecture of speech-in-noise deficits in individuals with self-reported normal hearing.

ABSTRACT: Speech-in-noise (SIN) perception is a primary complaint of individuals with audiometric hearing loss. SIN performance varies drastically, even among individuals with normal hearing. The present genome-wide association study (GWAS) investigated the genetic basis of SIN deficits in individuals with self-reported normal hearing in quiet situations. GWAS was performed on 279,911 individuals from the UB Biobank cohort, with 58,847 reporting SIN deficits despite reporting normal hearing in quiet. GWAS identified 996 single nucleotide polymorphisms (SNPs), achieving significance (p < 5*10^-8) across four genomic loci. 720 SNPs across 21 loci achieved suggestive significance (p < 10^-6). GWAS signals were enriched in brain tissues, such as the anterior cingulate cortex, dorsola

SUBMITTER: Bhatt IS 

PROVIDER: S-EPMC11161523 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature