Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis.

ABSTRACT: Living tissues display fluctuations-random spatial and temporal variations of tissue properties around their reference values-at multiple scales. It is believed that such fluctuations may enable tissues to sense their state or their size. Recent theoretical studies developed specific models of fluctuations in growing tissues and predicted that fluctuations of growth show long-range correlations. Here, we elaborated upon these predictions and we tested them using experimental data. We first introduced a minimal model for the fluctuations of any quantity that has some level of temporal persistence or memory, such as concentration of a molecule, local growth rate, or mechanical property. We found that long-range correlations are generic, applying to any such quantity, and that growth couples

SUBMITTER: Fruleux A 

PROVIDER: S-EPMC11161797 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature