Multisite Study of the Management of Musculoskeletal Infection After Trauma: The MMUSKIT Study.

ABSTRACT:

Background

The optimal duration and choice of antibiotic for fracture-related infection (FRI) is not well defined. This study aimed to determine whether antibiotic duration (≤6 vs >6 weeks) is associated with infection- and surgery-free survival. The secondary aim was to ascertain risk factors associated with surgery- and infection-free survival.

Methods

We performed a multicenter retrospective study of patients diagnosed with FRI between 2013 and 2022. The association between antibiotic duration and surgery- and infection-free survival was assessed by Cox proportional hazard models. Models were weighted by the inverse of the propensity score, calculated with a priori variables of hardware removal; infection due to Staphylococcus aureus, Staphylococcus lugdunensis<

SUBMITTER: Seidelman J 

PROVIDER: S-EPMC11161894 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature