Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.

ABSTRACT:

Context

Bu-shen-yi-jing-fang (BSYJF) has been reported to reduce amyloid-β (Aβ)_1-42 deposition in the brain of APP/PS1 mice and ameliorate cognitive function. However, its neuroprotective mechanism remains unclear.

Objective

This study aims to investigate whether BSYJF exerts a protective effect on Aβ_1-42-induced oxidative stress injury and explore its possible mechanism.

Materials and methods

The platform databases TCMSP, Swiss, TTD, DrugBank, and GeneCards were used to mine the targets of Alzheimer's disease (AD) and BSYJF. The platform databases STRING and Metascape were used to build the interaction network of the target protein, and Cytoscape software was used to analyze this network and screen out the key pathways. Aβ_1-42-treated

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11162075 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature