Synaptic wiring motifs in posterior parietal cortex support decision-making.

ABSTRACT: The posterior parietal cortex exhibits choice-selective activity during perceptual decision-making tasks^1-10. However, it is not known how this selective activity arises from the underlying synaptic connectivity. Here we combined virtual-reality behaviour, two-photon calcium imaging, high-throughput electron microscopy and circuit modelling to analyse how synaptic connectivity between neurons in the posterior parietal cortex relates to their selective activity. We found that excitatory pyramidal neurons preferentially target inhibitory interneurons with the same selectivity. In turn, inhibitory interneurons preferentially target pyramidal neurons with opposite selectivity, forming an opponent inhibition motif. This motif was present even between neurons with activity peaks in di

SUBMITTER: Kuan AT 

PROVIDER: S-EPMC11162200 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature