Transcription factor shapes chromosomal conformation and regulates gene expression in bacterial adaptation.

ABSTRACT: Genomic mutations allow bacteria to adapt rapidly to adverse stress environments. The three-dimensional conformation of the genome may also play an important role in transcriptional regulation and environmental adaptation. Here, using chromosome conformation capture, we investigate the high-order architecture of the Zymomonas mobilis chromosome in response to genomic mutation and ambient stimuli (acetic acid and furfural, derived from lignocellulosic hydrolysate). We find that genomic mutation only influences the local chromosome contacts, whereas stress of acetic acid and furfural restrict the long-range contacts and significantly change the chromosome organization at domain scales. Further deciphering the domain feature unveils the important transcription factors, Ferric uptake regulator

SUBMITTER: Chen M 

PROVIDER: S-EPMC11162768 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature