Prognostic and immunological significance of metastasis-associated protein 3 in patients with thymic epithelial tumors.

ABSTRACT:

Background

Immune checkpoint inhibitors have shown promising anticancer activity and have recently been proposed as a therapy for thymic epithelial tumors (TETs); however, this treatment is only effective for a subgroup of TET patients. Thus, this study aims to identify the potential genes implicated in the regulation of cancer immunity in TETs.

Methods

The TETs RNA-seq and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. The clinical significance of the tumor microenvironment (TME) in TETs was evaluated. Weighted gene coexpression network analysis (WGCNA) was used to identify the immune response-related hub genes. The expression of metastasis-associated protein 3 (MTA3) in TETs was investigated in public datasets and a patient cohort. Kaplan‒Meier c

SUBMITTER: Li J 

PROVIDER: S-EPMC11162987 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature