In silico bioprospecting of receptors associated with the mechanism of action of Rondonin, an antifungal peptide from spider <i>Acanthoscurria rondoniae</i> haemolymph.

ABSTRACT: Multiple drug-resistant fungal species are associated with the development of diseases. Thus, more efficient drugs for the treatment of these aetiological agents are needed. Rondonin is a peptide isolated from the haemolymph of the spider Acanthoscurria rondoniae. Previous studies have shown that this peptide has antifungal activity against Candida sp. and Trichosporon sp. strains, acting on their genetic material. However, the molecular targets involved in its biological activity have not yet been described. Bioinformatics tools were used to determine the possible targets involved in the biological activity of Rondonin. The PharmMapper server was used to search for microorganismal targets of Rondonin. The PatchDock server was used to perform the molecular docking. UCS

SUBMITTER: Muniz Seif EJ 

PROVIDER: S-EPMC11162988 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature