The association between circulating leukocytes and inflammatory bowel disease: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is a highly prevalent, recurrent, chronic intestinal inflammatory disease. Several observational studies have shown that circulating leukocytes are strongly associated with IBD. However, whether alterations in leukocytes are causally related to IBD remains uncertain. The present study explores this issue with the Mendelian randomization (MR) analysis method.

Methods

The Genome wide association study (GWAS) statistical data related to circulating leukocytes and IBD were obtained from the Blood Cell Consortium and the IEU Qpen GWAS project, respectively. Inverse variance weighting (IVW) was used as the main MR analytical method, coupled with a series of sensitivity analyses to ensure the reliability of the results.

Results

The

SUBMITTER: Tian L 

PROVIDER: S-EPMC11163050 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature