Durable-polymer versus biodegradable-polymer drug-eluting stents in acute coronary syndromes: three-year outcomes of the HOST REDUCE POLYTECH RCT Trial.

ABSTRACT:

Background

Long-term follow-up is essential to evaluate the impact of polymer degradation in drug-eluting stents (DES).

Aims

We aimed to compare durable-polymer DES (DP-DES) and biodegradable-polymer DES (BP-DES) during a 3-year follow-up to evaluate the entire period of polymer resolution (before, during, and after degradation).

Methods

The HOST REDUCE POLYTECH RCT Trial was a randomised clinical trial enrolling patients with acute coronary syndrome (ACS) and comparing the efficacy and safety of DP-DES and BP-DES. The primary outcome was a patient-oriented composite outcome (POCO), and the key secondary outcome was a device-oriented composite outcome (DOCO).

Results

A total of 3,413 ACS patients were randomised to either the DP-DES (1,713 patients) or BP-DES (

SUBMITTER: Kang J 

PROVIDER: S-EPMC11163442 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature