Plumieride as a novel anti-fungal and anti-inflammatory iridoid against superficial candidiasis in mice.

ABSTRACT: In the past few decades, there has been a notable rise in the occurrence of several types of candidiasis. Candida albicans is the most common cause of superficial fungal infections in humans. In this study, plumieride, one of the major iridoids from Plumeria obtusa L. leaves, was isolated and investigated for its potential against Candida albicans (CA)-induced dermatitis in mice. qRT-PCR was done to assess the impact of plumieride on the expression of the major virulence genes of CA. Five groups (n = 7) of adult male BALB/c mice were categorized into: group I: non-infected mice; group II: mice infected intradermally with 10⁷-10⁸ CFU/mL of CA; group III: CA-infected mice treated with standard fluconazole (50 mg/kg bwt.); group IV and V: CA-infected mice treated with pl

SUBMITTER: El-Shiekh RA 

PROVIDER: S-EPMC11163697 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature