CDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells.

ABSTRACT:

Background

Paraptosis is a programmed cell death characterized by cytoplasmic vacuolation, which has been explored as an alternative method for cancer treatment and is associated with cancer resistance. However, the mechanisms underlying the progression of paraptosis in cancer cells remain largely unknown.

Methods

Paraptosis-inducing agents, CPYPP, cyclosporin A, and curcumin, were utilized to investigate the underlying mechanism of paraptosis. Next-generation sequencing and liquid chromatography-mass spectrometry analysis revealed significant changes in gene and protein expressions. Pharmacological and genetic approaches were employed to elucidate the transcriptional events related to paraptosis. Xenograft mouse models were employed to evaluate the potential of paraptosis a

SUBMITTER: Chiang SK 

PROVIDER: S-EPMC11163730 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature