Neuroplasticity-related genes correlate with individual differences in distinct phases of oxycodone self-administration in male rats.

ABSTRACT: Opioid use disorder (OUD) is a chronic condition associated with long-lasting molecular and behavioral changes. Animals with prolonged access to opioids develop behaviors similar to human OUD. Identifying associated molecular changes can provide insight to underpinnings that lead to or maintain OUD. In pilot studies, we identified several miRNA targets that are altered by the administration of oxycodone. We selected mir182 for follow up as it was recently shown to be dysregulated in plasma of men administered oxycodone. In addition, mir182 is increased in reward-related brain regions of male rats following exposure to various addictive substances. The present study utilizes a long-access oxycodone self-administration paradigm to examine changes in mir182 and its mRNA targets associated wit

SUBMITTER: Vassoler FM 

PROVIDER: S-EPMC11164234 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature