Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity.

ABSTRACT:

Background

The mechanisms underlying the psychological and cardiovascular disease (CVD) benefits of physical activity (PA) are not fully understood.

Objectives

This study tested whether PA: 1) attenuates stress-related neural activity, which is known to potentiate CVD and for its role in anxiety/depression; 2) decreases CVD in part through this neural effect; and 3) has a greater impact on CVD risk among individuals with depression.

Methods

Participants from the Mass General Brigham Biobank who completed a PA survey were studied. A subset underwent ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomographic imaging. Stress-related neural activity was measured as the ratio of resting amygdalar-to-cortical activity (AmygA_C). CVD events

SUBMITTER: Zureigat H 

PROVIDER: S-EPMC11164527 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature