Dengue virus exploits autophagy vesicles and secretory pathways to promote transmission by human dendritic cells.

ABSTRACT: Dengue virus (DENV), transmitted by infected mosquitoes, is a major public health concern, with approximately half the world's population at risk for infection. Recent decades have increasing incidence of dengue-associated disease alongside growing frequency of outbreaks. Although promising progress has been made in anti-DENV immunizations, post-infection treatment remains limited to non-specific supportive treatments. Development of antiviral therapeutics is thus required to limit DENV dissemination in humans and to help control the severity of outbreaks. Dendritic cells (DCs) are amongst the first cells to encounter DENV upon injection into the human skin mucosa, and thereafter promote systemic viral dissemination to additional human target cells. Autophagy is a vesicle trafficking pathw

SUBMITTER: Cloherty APM 

PROVIDER: S-EPMC11165123 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature