A randomised trial of selective intracoronary hypothermia during primary PCI.

ABSTRACT:

Background

While experimental data suggest that selective intracoronary hypothermia decreases infarct size, studies in patients with ST-elevation myocardial infarction (STEMI) are lacking.

Aims

We investigated the efficacy of selective intracoronary hypothermia during primary percutaneous coronary intervention (PCI) to decrease infarct size in patients with STEMI.

Methods

In this multicentre randomised controlled trial, 200 patients with large anterior wall STEMI were randomised 1:1 to selective intracoronary hypothermia during primary PCI or primary PCI alone. Using an over-the-wire balloon catheter for infusion of cold saline and a pressure-temperature wire to monitor the intracoronary temperature, the anterior myocardium distal to the occlusion was selectively cool

SUBMITTER: El Farissi M 

PROVIDER: S-EPMC11165355 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature